Fumaric acid esters in the management of psoriasis
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منابع مشابه
Fumaric acid esters in the management of psoriasis
Fumaric acid esters (FAE) are small molecules with immunomodulating, anti-inflammatory, and anti-oxidative effects. FAE were introduced as a systemic psoriasis treatment in 1959 and empirically developed further between 1970 and 1990 in Germany, Switzerland, and the Netherlands. The development of FAE as psoriasis treatment did not follow the traditional drug development phases. Nonetheless, in...
متن کاملUse of fumaric acid esters in psoriasis.
Fumaric acid esters (FAE) are chemical compounds derived from the unsaturated dicarbonic acid fumaric acid. The usage of FAEs in treatment of psoriasis was introduced in the late 1950's. In the 1980s more standardized oral preparations of FAEs were developed containing dimethylfumarate (DMF) and salts of monoethylfumarate (MEF) as main compounds. In 1994, Fumaderm an enteric-coated tablet conta...
متن کاملReview of the Use of Fumaric Acid Esters in Dermatology
Background: Fumaric acid esters (FAE) have been used as a drug since 1959. The therapeutic preparation containing FAE has been one of the prominent drugs used for the systemic treatment of psoriasis since 1994 in Germany. FAE have been used in the treatment of sarcoidosis, granuloma annulare, necrobiosis lipoidica, cheilitis granulomatosa, annular elastotic giant cell granuloma, malignant melan...
متن کاملIn vitro pharmacokinetics of anti-psoriatic fumaric acid esters
BACKGROUND Psoriasis is a chronic inflammatory skin disease that can be successfully treated with a mixture of fumaric acid esters (FAE) formulated as enteric-coated tablets for oral use. These tablets consist of dimethylfumarate (DMF) and salts of monoethylfumarate (MEF) and its main bioactive metabolite is monomethylfumarate (MMF). Little is known about the pharmacokinetics of these FAE. The ...
متن کاملDrug-induced Fanconi syndrome associated with fumaric acid esters treatment for psoriasis: a case series
BACKGROUND Fumaric acid esters (FAEs), an oral immunomodulating treatment for psoriasis and multiple sclerosis, have been anecdotally associated with proximal renal tubular dysfunction due to a drug-induced Fanconi syndrome. Few data are available on clinical outcomes of FAE-induced Fanconi syndrome. METHODS Descriptive case series with two cases of Fanconi syndrome associated with FAE treatm...
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ژورنال
عنوان ژورنال: Psoriasis: Targets and Therapy
سال: 2015
ISSN: 2230-326X
DOI: 10.2147/ptt.s51490